Reaktion #811136

Reaktionsgleichung

amino urea

(2-Amino-benzothiazol-5-yl)-thiourea

thiophene-2-carboximidothioic acid phenyl ester hydrobromide

→

N-(2-Amino-benzothiazol-5-yl)-thiophene-2-carboxamidine hydrobromide

Lösungsmittel

diethyl ether

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe light yellow precipitate was collected by filtration (64.8 mg, 93%)

Vorschrift

To a solution of the amino urea compound (Example 18, 35 mg, 0.21 mmol) in ethanol (1.4 mL) was added thiophene-2-carboximidothioic acid phenyl ester hydrobromide (63.7 mg, 0.21 mmol). The mixture was stirred at room temperature for 17 hours and then diluted with diethyl ether. The light yellow precipitate was collected by filtration (64.8 mg, 93%). 1H-NMR (DMSO d6) δ: 11.36 (br s, 1H), 9.72 (br s, 1H), 8.83 (br s, 1H), 8.17 (d, 1H, J=4.68 Hz).

Quelle