Reaktion #81103

Reaktionsgleichung

ethyl α-chloro-α-formylacetate

thioformamide

→

desired compound

Ausbeute 33.0%

5-(Carbethoxy)thiazole

Ausbeute 33.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONdistilled

Vorschrift

According to the procedure of Mashraqui and Keehn (J. Am. Chem. Soc. 1982, 104, 4461), ethyl α-chloro-α-formylacetate was condensed with thioformamide and vacuum distilled to provide 5.65 g (33%) of the desired compound.

Quelle