Reaktion #810707

Reaktionsgleichung

methyl 6-amino-5-bromopyridine-2-carboxylate

N-chlorosuccinimide

→

product

Ausbeute 95.5%

Methyl 6-amino-5-bromo-3-chloropyridine-2-carboxylate

Ausbeute 95.5%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solution was then evaporated
2. 2
   workup.ADDITIONtreated with excess aqueous sodium bicarbonate
3. 3
   Extraktionextracted with dichloromethane
4. 4
   SonstigeThe organic fraction was dried
5. 5
   Sonstigeevaporated

Vorschrift

To a solution methyl 6-amino-5-bromopyridine-2-carboxylate (20.04 g) in acetic acid (900 ml) was added N-chlorosuccinimide (13.96 g) and the resultant solution was heated to 120° C. for 1 hour. The solution was then evaporated and treated with excess aqueous sodium bicarbonate and extracted with dichloromethane. The organic fraction was dried and evaporated to give the product (21.98 g).

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