Reaktion #81032

Reaktionsgleichung

2,6-Di-tert-butylphenol

4-cyano-benzaldehyde

piperidine

→

title compound

2,6-Di-tert-butyl-4-[4-cyano-α-(piperidin-1-yl )benzyl]phenol

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solution is then evaporated in vacuo
2. 2
   Sonstigethe residue chromatographed on silica gel with toluene/ethyl acetate (9:1)

Vorschrift

2,6-Di-tert-butylphenol (4.12 g, 0.02 mol), 2.62 g (0.02 mol) of 4-cyano-benzaldehyde and 1.7 g (0.02 mol) of piperidine are refluxed under nitrogen in 25 ml of xylene for 24 hours. The solution is then evaporated in vacuo and the residue chromatographed on silica gel with toluene/ethyl acetate (9:1) to give 6.2 g of a practically pure title compound. A 5 g portion of said compound is recrystallized twice from acetonitrile to give 1.0 g of a pure sample as colorless crystals, melting at 139°-140° C.

Quelle