Reaktion #80996

ord-3615544b7697404c86ec6836a57e781d

Reaktionsgleichung

CO
methanol
CC(C)C(N)=S
2-methylpropane-thioamide
CCOC(C)=O
ethyl acetate
CCCCCC
hexane
→
CCOC(=O)c1cnc(C(C)C)s1
desired compound
Ausbeute 83.0%
CCOC(=O)c1cnc(C(C)C)s1
Ethyl 2-Isopropylthiazole-5-carboxylate
Ausbeute 83.0%

Edukte

CO
methanol
CC(C)C(N)=S
2-methylpropane-thioamide
CCOC(C)=O
ethyl acetate
CCCCCC
hexane

Reagenzien

Keine

Lösungsmittel

ClC(Cl)Cl
chloroform

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeprovided

Vorschrift

Using the procedure of Example 1J but replacing thioformamide with 2-methylpropane-thioamide provided, after silica gel chromatography using 9:1 ethyl acetate:hexane, the desired compound, Rf 0.8, (5% methanol in chloroform) in 83% yield.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05616720uspto-grants-1997_04