Reaktion #80992

Reaktionsgleichung

N,N-diethylthiourea

ethyl bromopyruvate

MgSO4

→

desired compound

Ausbeute 140.4%

Ethyl 2-(N,N-Diethylamino)thiazole-4-carboxylate

Ausbeute 140.4%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux for 1 h
3. 3
   FiltrationThe resulting mixture was filtered
4. 4
   Einengenconcentrated in vacuo

Vorschrift

A solution of 0.972 g (7.36 mmol) of N,N-diethylthiourea and 1.02 ml (8.1 mmol) of ethyl bromopyruvate in 25 ml of acetone was treated with excess solid MgSO4 and heated at reflux for 1 h. The resulting mixture was filtered, and concentrated in vacuo. Silica gel chromatography using CHCl3 provided 2.36 g (38%) of the desired compound as an oil. Mass spectrum: (M+H)+ =229.

Quelle