Reaktion #809898

Reaktionsgleichung

α-phenylcyclopentaneacetyl chloride

3-Methyl-2-phenyl-pentanoic acid (3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-amide

2-Amino-3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophene

→

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-cyclopentyl-2-phenyl-acetamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprovided after workup, crude product which
2. 2
   Sonstigetriturated with diethylether
3. 3
   Sonstigeto give 111 mg of which
4. 4
   Sonstigewas further purified by recrystallization from ethylacetate/hexanes

Vorschrift

Reaction of α-phenylcyclopentaneacetyl chloride (Prepared in Example 12, Step1) and 2-Amino-3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophene (164 mg; 1.0 mmol) according to the procedure outlined in Example 5 for 20 h at room temperature provided after workup, crude product which triturated with diethylether to give 111 mg of which was further purified by recrystallization from ethylacetate/hexanes to provide 44 mg (%) of N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-cyclopentyl-2-phenyl-acetamide as a light brown solid. EI-HRMS m/e calcd for C21H32N2OS (M+) 350.1453, found 350.1456.

Quelle