Reaktion #80986

Reaktionsgleichung

4-chloromethyl-4-hydroxy-2-isopropyloxazoline

SOCl2

→

desired compound

Ausbeute 96.0%

Chloromethyl-2-isopropyloxazole

Ausbeute 96.0%

Lösungsmittel

1,2-dichloroethane

1,2-dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction was cooled to room temperature
2. 2
   Sonstigethe solvent removed by rotary evaporation in vacuo
3. 3
   SonstigeDrying the residue on high vacuum

Vorschrift

A solution of 4-chloromethyl-4-hydroxy-2-isopropyloxazoline (4.88 g, 0.0275 mol) in 1,2-dichloroethane (20 mL) was added to a solution of SOCl2 (2.40 mL, 0.0329 mol) in 1,2-dichloroethane (80 mL) at 0° C. under argon, and the solution was heated to 70° C. After 15 min at 70° C., the reaction was cooled to room temperature and the solvent removed by rotary evaporation in vacuo. Drying the residue on high vacuum gave the desired compound as a brown semi-solid (4.20 g, 0.0263 mol, 96%): 1H NMR (CDCl3) δ1.36 (d, J=7.5 Hz, 6H), 3.03-3.18 (m, 1H), 4.50 (s, 2H), 7.56 (s 1H). Mass spectrum: (M+H)+ =160, 162.

Quelle