Reaktion #809027

Reaktionsgleichung

4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-3-fluoroaniline

toluene

3-(methylsulfanyl)propanoyl chloride

3-(Methylsulfanyl)propanoyl isothiocyanate

→

title compound

Ausbeute 50.0%

N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-[3-(methylsulfanyl)propanoyl]thiourea

Ausbeute 50.0%

3-(Methylsulfanyl)propanoyl isothiocyanate

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto prepare a solution
2. 2
   EinengenThe reaction solution was concentrated
3. 3
   Sonstigethe residue was purified by chromatography on silica gel

Vorschrift

3-(Methylsulfanyl)propanoyl isothiocyanate was prepared using commercially available 3-(methylsulfanyl)propanoyl chloride (80 mg) as a starting compound according to the description of the literature. 3-(Methylsulfanyl)propanoyl isothiocyanate was dissolved in ethanol (1 ml) to prepare a solution. 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-3-fluoroaniline (50 mg), toluene (5 ml), and ethanol (1 ml) were added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (38 mg, yield 50%).

Quelle