Reaktion #809026

Reaktionsgleichung

4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-3-fluoroaniline

toluene

4-chlorobutanoyl chloride

4-Chlorobutanoyl isothiocyanate

→

title compound

Ausbeute 54.0%

N-(4-Chlorobutanoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea

Ausbeute 54.0%

4-Chlorobutanoyl isothiocyanate

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto prepare a solution
2. 2
   EinengenThe reaction solution was concentrated
3. 3
   Sonstigethe residue was purified by chromatography on silica gel

Vorschrift

4-Chlorobutanoyl isothiocyanate was prepared using commercially available 4-chlorobutanoyl chloride (80 mg) as a starting compound according to the description of the literature. 4-Chlorobutanoyl isothiocyanate was dissolved in ethanol (1 ml) to prepare a solution. 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-3-fluoroaniline (50 mg), toluene (5 ml), and ethanol (1 ml) were added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (41 mg, yield 54%).

Quelle