Reaktion #808971

Reaktionsgleichung

4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluoroaniline

toluene

2,4-difluoro-1-benzenecarbonyl chloride

2,4-Difluoro-1-benzenecarbonyl isothiocyanate

→

title compound

Ausbeute 81.0%

N-(2,4-Difluorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea

Ausbeute 81.0%

2,4-Difluoro-1-benzenecarbonyl isothiocyanate

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto prepare a solution
2. 2
   EinengenThe reaction solution was concentrated
3. 3
   Sonstigethe residue was purified by chromatography on silica gel

Vorschrift

2,4-Difluoro-1-benzenecarbonyl isothiocyanate was prepared using commercially available 2,4-difluoro-1-benzenecarbonyl chloride (80 mg) as a starting compound according to the description of the literature. 2,4-Difluoro-1-benzenecarbonyl isothiocyanate was dissolved in ethanol (1 ml) to prepare a solution. 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluoroaniline (50 mg), toluene (5 ml), and ethanol (1 ml) were added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (66 mg, yield 81%).

Quelle