Reaktion #808958

Reaktionsgleichung

4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluoroaniline

4-(chloromethyl)-1-benzenecarbonyl chloride

4-(chloromethyl)-1-benzenecarbonyl isothiocyanate

→

4-(Chloromethyl)-1-benzenecarbonyl isothiocyanate

title compound

Ausbeute 81.0%

N-[4-(Chloromethyl)benzoyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea

Ausbeute 81.0%

Lösungsmittel

toluene

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction solution was concentrated
2. 2
   Sonstigethe residue was purified by chromatography on silica gel

Vorschrift

4-(Chloromethyl)-1-benzenecarbonyl isothiocyanate was prepared using commercially available 4-(chloromethyl)-1-benzenecarbonyl chloride (80 mg) as a starting compound according to the description of the literature. 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluoroaniline (50 mg) was dissolved in toluene (5 ml) and ethanol (1 ml) to prepare a solution. A solution of 4-(chloromethyl)-1-benzenecarbonyl isothiocyanate in ethanol (1 ml) was then added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (68 mg, yield 81%).

Quelle