Reaktion #808915

Reaktionsgleichung

4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline

3-methoxy-1-benzenecarbonyl chloride

3-methoxy-1-benzenecarbonyl isothiocyanate

→

title compound

Ausbeute 81.0%

N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl}-N′-(3-methoxybenzoyl)thiourea

Ausbeute 81.0%

3-Methoxy-1-benzenecarbonyl isothiocyanate

Lösungsmittel

toluene

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction solution was concentrated
2. 2
   Sonstigethe residue was purified by chromatography on silica gel

Vorschrift

3-Methoxy-1-benzenecarbonyl isothiocyanate was prepared using commercially available 3-methoxy-1-benzenecarbonyl chloride (80 mg) as a starting compound according to the description of the literature. 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (50 mg) was dissolved in toluene (5 ml) and ethanol (1 ml) to prepare a solution. A solution of 3-methoxy-1-benzenecarbonyl isothiocyanate in ethanol (1 ml) was then added to the solution, and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (67 mg, yield 81%).

Quelle