Reaktion #8089

Reaktionsgleichung

sodium hydrogencarbonate

4-methoxycarbonyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one

potassium carbonate

isobutyl bromide

→

title compound

Ausbeute 65.1%

4-carboxy-2-isobutyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one

Ausbeute 65.1%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto drop back to room temperature
2. 2
   ExtraktionThe mixture was then extracted with ethyl acetate
3. 3
   WaschenThe extract was washed with brine
4. 4
   Trocknendried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off
6. 6
   Sonstigethe residue was reacted

Vorschrift

To a solution of 4-methoxycarbonyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one (8.00 g, 29.0 mmol) in N,N-dimethylformamide (80 mL) were added potassium carbonate (8.02 g, 58.0 mmol) and isobutyl bromide (4.76 g, 34.8 mmol), and the mixture was stirred at 80° C. for 2 hours. The temperature of the reaction mixture was allowed to drop back to room temperature, and a saturated aqueous solution of sodium hydrogencarbonate was added. The mixture was then extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was distilled off. Following the procedure of Example 1 (7), the residue was reacted to yield the title compound as a yellow solid [yield: 65.1% (2 steps)].

Quelle