Reaktion #80873

ord-e9a0414aba054e69bac783df1acedb20

Reaktionsgleichung

NC(=N[N+](=O)[O-])NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)O
(R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine
COc1ccc(CCN)cc1
4-methoxybenzenethanamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
→
COc1ccc(CCNC(=O)[C@H](CCCNC(N)=N[N+](=O)[O-])NC(=O)C(c2ccccc2)c2ccccc2)cc1
N5 -[Amino(nitroimino)methyl]-N2 -(diphenylacetyl)-N-[2-(4-methoxyphenyl)ethyl]-ornithinamide
Ausbeute 47.0%

Edukte

NC(=N[N+](=O)[O-])NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)O
(R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine
COc1ccc(CCN)cc1
4-methoxybenzenethanamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 8a) from (R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine, 4-methoxybenzenethanamine and TBTU in a yield of 47% of theory.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05616620uspto-grants-1997_04