Reaktion #80872

ord-720ce748ea8a472794c951ecc6654248

Reaktionsgleichung

NC(=N[N+](=O)[O-])NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)O
(R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine
NCc1ccc(-c2ccc(O)cc2)cc1
4'-hydroxy-[1,1'-biphenyl]-4-methanamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
→
NC(=N[N+](=O)[O-])NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(-c2ccc(O)cc2)cc1
N5 -[Amino(nitroimino)methyl]-N2 -(diphenylacetyl)-N-[(4'-hydroxy-[1,1'-biphenyl]-4-yl)methyl]-ornithinamide
Ausbeute 48.0%

Edukte

NC(=N[N+](=O)[O-])NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)O
(R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine
NCc1ccc(-c2ccc(O)cc2)cc1
4'-hydroxy-[1,1'-biphenyl]-4-methanamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 5d) from (R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine, 4'-hydroxy-[1,1'-biphenyl]-4-methanamine and TBTU in a yield of 48% of theory.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05616620uspto-grants-1997_04