Reaktion #80867

ord-6d677ec2b72145d791b9f514477f819b

Reaktionsgleichung

CC(C)(C)OC(=O)N[C@H](CCCNC(N)=N[N+](=O)[O-])C(=O)NCc1cc(Br)c(N)c(Br)c1
(R)-N-[(4-amino-3,5-dibromophenyl)methyl]-N5 -[amino(nitroimino)methyl]-N2 -[(tert.-butyloxy)carbonyl]-ornithinamide
Cl
hydrochloric acid
→
Cl.NC(=N[N+](=O)[O-])NCCC[C@@H](N)C(=O)NCc1cc(Br)c(N)c(Br)c1
(R)-N-[(4-Amino-3,5-dibromophenyl)methyl]-N5 -[amino(nitroimino)methyl]-ornithinamide-hydrochloride

Edukte

CC(C)(C)OC(=O)N[C@H](CCCNC(N)=N[N+](=O)[O-])C(=O)NCc1cc(Br)c(N)c(Br)c1
(R)-N-[(4-amino-3,5-dibromophenyl)methyl]-N5 -[amino(nitroimino)methyl]-N2 -[(tert.-butyloxy)carbonyl]-ornithinamide
Cl
hydrochloric acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 36b) from (R)-N-[(4-amino-3,5-dibromophenyl)methyl]-N5 -[amino(nitroimino)methyl]-N2 -[(tert.-butyloxy)carbonyl]-ornithinamide by treating with methanolic hydrochloric acid in a quantitative yield.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05616620uspto-grants-1997_04