Reaktion #80857

ord-db9262c8186e4a15876f0f001703f7da

Reaktionsgleichung

CC(C)(C)OC(=O)N[C@H](CCCN=C(N)N[N+](=O)[O-])C(=O)O
Boc-D-Arg (NO2)-OH
NCc1ccc(Cl)cc1
(4-chlorophenyl) methylamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
→
CC(C)(C)OC(=O)N[C@H](CCCNC(N)=N[N+](=O)[O-])C(=O)NCc1ccc(Cl)cc1
(R)-N-[(4-Chlorophenyl) methyl]-N5 -[amino (nitroimino) methyl]-N2 -(tert. -butoxycarbonyl)-ornithinamide
Ausbeute 87.0%

Edukte

CC(C)(C)OC(=O)N[C@H](CCCN=C(N)N[N+](=O)[O-])C(=O)O
Boc-D-Arg (NO2)-OH
NCc1ccc(Cl)cc1
(4-chlorophenyl) methylamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 5d) from Boc-D-Arg (NO2)-OH, (4-chlorophenyl) methylamine and TBTU in a yield of 87% of theory.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05616620uspto-grants-1997_04