Reaktion #8082

ord-9099d3a220c64814acf549559f07b0ba

Reaktionsgleichung

Cc1cc(-c2cc(COS(C)(=O)=O)c(=O)n(CC=Cc3ccccc3)n2)ccc1F
2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
CNC
dimethylamine
→
Cc1cc(-c2cc(CN(C)C)c(=O)n(CC=Cc3ccccc3)n2)ccc1F
title compound
Ausbeute 90.9%
Cc1cc(-c2cc(CN(C)C)c(=O)n(CC=Cc3ccccc3)n2)ccc1F
2-cinnamyl-4-dimethylaminomethyl-6-(4-fluoro-3-methyl phenyl)-2H-pyridazin-3-one
Ausbeute 90.9%

Edukte

Cc1cc(-c2cc(COS(C)(=O)=O)c(=O)n(CC=Cc3ccccc3)n2)ccc1F
2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
CNC
dimethylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere reacted

Vorschrift

Following the procedure of Example 7, 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a yellow oil (yield: 90.9%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08