Reaktion #8078

ord-fcf274a54078452a9ad50b4702e61f52

Reaktionsgleichung

CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
( 7 )
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccc(F)c(C)c2)nn(CC=Cc2ccccc2)c1=O
2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one
→
Cc1cc(-c2cc(C(=O)O)c(=O)n(CC=Cc3ccccc3)n2)ccc1F
title compound
Ausbeute 85.1%
Cc1cc(-c2cc(C(=O)O)c(=O)n(CC=Cc3ccccc3)n2)ccc1F
4-carboxy-2-cinnamyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one
Ausbeute 85.1%

Edukte

CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
( 7 )
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccc(F)c(C)c2)nn(CC=Cc2ccccc2)c1=O
2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (7), 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as pale yellow needles (yield: 85.1%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08