Reaktion #807595

Reaktionsgleichung

5-Chloro-1-phenacyl-quinolinium bromide

2-bromo-1-phenyl-ethanone

6-chloro-quinoline

→

title compound

1-Benzoyl-6-chloro-3-cyano-pyrrolo[1,2-a]quinoline

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeyielded 394 mg (57%) as a light tan solid

Vorschrift

5-Chloro-1-phenacyl-quinolinium bromide: The title compound was prepared from 2-bromo-1-phenyl-ethanone (490 mg, 2.46 mmol), 6-chloro-quinoline (314 mg, 1.92 mmol) and acetonitrile (5 mL), similar to Example 1a, and yielded 394 mg (57%) as a light tan solid: 1H NMR (CDCl3) 10.55 (dd, J=1.2, 6.0 Hz, 1H), 9.41 (d, J=8.7 Hz, 1H), 8.32 (m, 1H), 8.30 (m, 1H), 8.23 (dd, J=6.0, 9.0 Hz, 1H), 8.05–7.99 (m, 3H), 7.70 (m, 3H), 7.55 (m, 2H).

Quelle