Reaktion #807337

Reaktionsgleichung

tert-butyl [(1R)-1-({[2-(6-methylpyridin-3-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]amino}carbonyl)-3-phenylpropyl]carbamate

→

title compound

Ausbeute 48.0%

(2R)-2-Amino-N-[2-(6-methyl-pyridin-3-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-4-phenyl-butyramide

Ausbeute 48.0%

Lösungsmittel

—

dioxanes

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was then filtered
2. 2
   Waschenthe solid material washed thoroughly with ethyl ether

Vorschrift

A suspension of tert-butyl [(1R)-1-({[2-(6-methylpyridin-3-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]amino}carbonyl)-3-phenylpropyl]carbamate 267(c) in 5 mL of 4M HCl in dioxanes was stirred at room temperature for two hours. The mixture was then filtered and the solid material washed thoroughly with ethyl ether. The title compound was obtained as a yellow solid in 48% yield after purification by reverse-phase HPLC.

Quelle