Reaktion #807277

Reaktionsgleichung

title compound

8-Amino-2-phenyl-1,5-dihydro-[1,2]diazepino[4,5,6-cd]indol-6-one

4-Phenyl-butyric acid

triethylamine

O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate

→

title compound

Ausbeute 33.0%

N-(6-Oxo-2-phenyl-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)-4-phenyl-butyramide

Ausbeute 33.0%

Lösungsmittel

N,N-dimethylformamide

CH2Cl2 methanol

Reaktionsbedingungen

Vorschrift

Preparation of example 36 from the title compound of Example 7 (0.030 g, 0.11 mmol), 4-Phenyl-butyric acid (0.027 g, 0.16 mmol), triethylamine (0.077 mL, 0.44 mmol), O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (63 mg, 0.16 mmol) and N,N-dimethylformamide (0.05 M, 2.0 mL) was carried out analogously to Example 11. Silica gel chromatography (95:5 CH2Cl2/methanol) afforded the title compound (15 mg) as a yellow powder in 33% yield.

Quelle