Reaktion #8067

ord-394277e0d63a4f63977661e2548de12b

Reaktionsgleichung

Cc1c(-c2ccc(F)c(F)c2)nn(CC(C)C)c(=O)c1N1CCN(C(=O)OC(C)(C)C)CC1
( 8 )
Cc1c(-c2ccc(F)c(F)c2)nn(CC(C)C)c(=O)c1N1CCN(C(=O)OC(C)(C)C)CC1
4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(C(=O)O)c1=O
4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one
→
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(CO)c1=O
title compound
Ausbeute 45.0%
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(CO)c1=O
6-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one
Ausbeute 45.0%

Edukte

Cc1c(-c2ccc(F)c(F)c2)nn(CC(C)C)c(=O)c1N1CCN(C(=O)OC(C)(C)C)CC1
( 8 )
Cc1c(-c2ccc(F)c(F)c2)nn(CC(C)C)c(=O)c1N1CCN(C(=O)OC(C)(C)C)CC1
4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(C(=O)O)c1=O
4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (8), 4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow oil (yield: 45.0%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08