Reaktion #806511

ord-f6ee2e41f3e4460f9237787acfbcc012

Reaktionsgleichung

Nc1nc(-c2cccnc2)cs1
4-(3-pyridyl)-1,3-thiazol-2-amine
O=S(=O)(Cl)c1c(Cl)cc(Cl)cc1Cl
2,4,6-trichlorobenzenesulfonyl chloride
→
O=S(=O)(Nc1nc(-c2cccnc2)cs1)c1c(Cl)cc(Cl)cc1Cl
title compound
O=S(=O)(Nc1nc(-c2cccnc2)cs1)c1c(Cl)cc(Cl)cc1Cl
2,4,6-Trichloro-N-[4-(3-pyridinyl)-1,3-thiazol-2-yl]benzenesulfonamide

Edukte

Nc1nc(-c2cccnc2)cs1
4-(3-pyridyl)-1,3-thiazol-2-amine
O=S(=O)(Cl)c1c(Cl)cc(Cl)cc1Cl
2,4,6-trichlorobenzenesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 4-(3-pyridyl)-1,3-thiazol-2-amine and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (29.3 mg) with purity >90%: MS (pos) m/z 422.1; HRMS m/z 418.9134 (calc. of monoisotopic mass for C14H8Cl3N3O2S2 gives 418.9123).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07132436B2uspto-grants-2006_11