Reaktion #806371

Reaktionsgleichung

4-methoxy-benzo[a]phenazine-11-carboxylic acid methyl ester

1-dimethylamino-2-propylamine

→

title compound

4-Methoxy-benzo[a]phenazine-11-carboxylic acid (2-dimethylamino-1-methyl-ethyl)-amide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was then cooled
2. 2
   Sonstigethe excess amine was removed in vacuo
3. 3
   SonstigeThe residue was then purified

Vorschrift

A mixture of 4-methoxy-benzo[a]phenazine-11-carboxylic acid methyl ester (IV.1) (350 mg) and 1-dimethylamino-2-propylamine (2 mL)(commercially available) was heated to 110° C. under N2 for 4 hours. The reaction mixture was then cooled and the excess amine was removed in vacuo. The residue was then purified using flash chromatography (silica, ethyl acetate and then 25% methanol in ethyl acetate) to yield the title compound as a yellow solid (164 mg).

Quelle