Reaktion #806079

Reaktionsgleichung

(S)-1,1-diethoxypropan-2-amine

5-chlorothieno[3,2-b]pyridine-3-carbaldehyde

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title compound

Ausbeute 30.3%

(S)—N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine

Ausbeute 30.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepurified on Buch silica gel column chromatography (chloroform:methanol=98:2 to 95:5)

Vorschrift

According to the procedure described in the synthesis method of Compound IX-2, (S)-1,1-diethoxypropan-2-amine (Compound XIX-1) 1.98 g (13.4 mmol) was reacted with 5-chlorothieno[3,2-b]pyridine-3-carbaldehyde (Compound XX-1) 1.98 g (10 mmol) and purified on Buch silica gel column chromatography (chloroform:methanol=98:2 to 95:5) to obtain the title compound 996 mg (30%).

Quelle