Reaktion #8059

ord-fdde27bcafa44772a696d31f27493e13

Reaktionsgleichung

Cc1cc(-c2cc(CN3CCN(C)CC3)c(=O)n(CC(C)C)n2)ccc1F
( 8 )
Cc1cc(-c2cc(CN3CCN(C)CC3)c(=O)n(CC(C)C)n2)ccc1F
6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)c(F)c2)cc(C(=O)O)c1=O
4-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one
→
CC(C)Cn1nc(-c2ccc(F)c(F)c2)cc(CO)c1=O
title compound
Ausbeute 25.0%
CC(C)Cn1nc(-c2ccc(F)c(F)c2)cc(CO)c1=O
6-(3,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one
Ausbeute 25.0%

Edukte

Cc1cc(-c2cc(CN3CCN(C)CC3)c(=O)n(CC(C)C)n2)ccc1F
( 8 )
Cc1cc(-c2cc(CN3CCN(C)CC3)c(=O)n(CC(C)C)n2)ccc1F
6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)c(F)c2)cc(C(=O)O)c1=O
4-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (8), 4-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine-needles (yield: 25.0%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08