Reaktion #805883

ord-474607dac57341f1baf44643dcbde753

Reaktionsgleichung

CCOC(=O)c1cccc2nc(CP(=O)(OCC)OCC)ccc12
Compound 73d
CCOC(=O)c1cccc2nc(CP(=O)(OCC)OCC)ccc12
Ethyl-2-[(diethoxyphosphoryl]methyl)quinoline-5-carboxylate
COc1cccc(-c2c(C=O)nc3c(N4CCOCC4)ccnn23)c1
compound 77a
COc1cccc(-c2c(C=O)nc3c(N4CCOCC4)ccnn23)c1
3-(3-Methoxyphenyl)-8-morpholinoimidazo[1,2-b]pyridazine-2-carbaldehyde
→
COc1cccc(-c2c(/C=C/c3ccc4c(C(=O)O)cccc4n3)nc3c(N4CCOCC4)ccnn23)c1
compound 77b
COc1cccc(-c2c(/C=C/c3ccc4c(C(=O)O)cccc4n3)nc3c(N4CCOCC4)ccnn23)c1
(E)-2-(2-(3-(3-methoxyphenyl)-8-morpholinoimidazo[1,2-b]pyridazin-2-yl)vinyl)quinoline-5-carboxylic acid

Edukte

CCOC(=O)c1cccc2nc(CP(=O)(OCC)OCC)ccc12
Compound 73d
CCOC(=O)c1cccc2nc(CP(=O)(OCC)OCC)ccc12
Ethyl-2-[(diethoxyphosphoryl]methyl)quinoline-5-carboxylate
COc1cccc(-c2c(C=O)nc3c(N4CCOCC4)ccnn23)c1
compound 77a
COc1cccc(-c2c(C=O)nc3c(N4CCOCC4)ccnn23)c1
3-(3-Methoxyphenyl)-8-morpholinoimidazo[1,2-b]pyridazine-2-carbaldehyde

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Compound 73d (53 mg, 0.15 mmol) was reacted under Horner-Emmons coupling conditions with compound 77a (51 mg, 0.15 mmol) using the procedures described in Example 20, Step A to afford compound 77b. Mass spectrum (LCMS, ESI pos.) Calcd. For C29H25N5O4 508.2 (M+H). found 508.2.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09193736B2uspto-grants-2015_11