Reaktion #805851

Reaktionsgleichung

Compound 58d

(E)-Methyl 4-(8-morpholino-2-(2-(5,6,7,8-tetrahydroquinolin-2-yl)vinyl)imidazo[1,2-b]pyridazin-3-yl)benzoate

LiOH

→

title compound 76

(E)-4-(8-Morpholino-2-(2-(5,6,7,8-tetrahydroquinolin-2-yl)vinyl)imidazo[1,2-b]pyridazin-3-yl)benzoic acid

Reaktionsbedingungen

Vorschrift

Compound 58d (0.30 g, 0.74 mmol) was hydrolyzed with LiOH using the procedure described in Example 54, Step E to obtain the title compound 76 as a yellow solid. 1H-NMR (300 MHz, DMSO-d6) δ (ppm): 13.00 (br, 1H), 8.14-8.11 (m, 3H), 7.81 (d, J=8.1 Hz, 2H), 7.60-7.49 (m, 2H), 7.43 (d, J=8.1 Hz, 1H), 7.33 (d, J=8.1 Hz, 1H), 6.43 (d, J=5.7 Hz, 1H), 4.07-4.02 (m, 4H), 3.85-3.83 (m, 4H), 2.78-2.73 (m, 4H), 1.80-1.75 (m, 4H). Mass Spectrum (LCMS, ESI pos.): Calcd. for C28H27N5O3: 482.2 (M+H). Found: 482.1.

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