Reaktion #8057

ord-af73b051fe144fdba335731eb1906f61

Reaktionsgleichung

Cc1cc(-c2nn(CC(C)C)c(=O)c(O)c2C)ccc1F
( 6 )
Cc1cc(-c2nn(CC(C)C)c(=O)c(O)c2C)ccc1F
6-(4-fluoro-3-methylphenyl)-4-hydroxy-methyl-2-isobutyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccc(F)c(F)c2)n[nH]c1=O
6-(3,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one
→
COC(=O)c1cc(-c2ccc(F)c(F)c2)nn(CC(C)C)c1=O
title compound
COC(=O)c1cc(-c2ccc(F)c(F)c2)nn(CC(C)C)c1=O
6-(3,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

Edukte

Cc1cc(-c2nn(CC(C)C)c(=O)c(O)c2C)ccc1F
( 6 )
Cc1cc(-c2nn(CC(C)C)c(=O)c(O)c2C)ccc1F
6-(4-fluoro-3-methylphenyl)-4-hydroxy-methyl-2-isobutyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccc(F)c(F)c2)n[nH]c1=O
6-(3,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (6), 6-(3,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow oil (yield: quantitative).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08