Reaktion #805326

Reaktionsgleichung

2-(4-Fluorophenyl)acetonitrile

ethanol

HCl

→

ethyl 2-(4-fluorophenyl)acetimidate hydrochloride

Ausbeute 100.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred for 6 h
2. 2
   SonstigeOrganic solvent was removed in vacuo

Vorschrift

2-(4-Fluorophenyl)acetonitrile (1.0 g, 7.4 mmol) was dissolved in anhydrous ethanol (2 mL) under an atmosphere of Ar. The solution was cooled to 0° C., saturated with HCl gas, stirred for 6 h, allowed to warm to RT, and stirred for 6 h. Organic solvent was removed in vacuo to afford ethyl 2-(4-fluorophenyl)acetimidate hydrochloride (1.6 g, 100%) as a white solid. 1H NMR (400 MHz, DMSO-d6): δ 12.27 (m, 1H), 11.20 (m, 1H), 7.40 (dd, J=8.3, 5.5 Hz, 2H), 7.19 (t, J=8.8 Hz, 2H), 4.38 (q, J=7.0 Hz, 2H), 3.99 (s, 2H), 1.25 (t, J=7.0 Hz, 3H).

Quelle