Reaktion #8043

ord-b6623aafc3be420190abc80d4c625a60

Reaktionsgleichung

Cc1ccc(-c2cc(CN3CCN(Cc4ccccc4)CC3)c(=O)n(CC(C)C)n2)cc1
( 5 )
Cc1ccc(-c2cc(CN3CCN(Cc4ccccc4)CC3)c(=O)n(CC(C)C)n2)cc1
4-(4-benzyl-1-piperazinyl)methyl-2-isobutyl-6-(4-methylphenyl)-2H-pyridazin-3-one
O=C(O)c1cc(-c2ccc(C(F)(F)F)cc2)n[nH]c1=O
4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one
→
COC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)n[nH]c1=O
title compound
COC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)n[nH]c1=O
4-methoxycarbonyl-6-(4-trifluoromethyl-phenyl)-2H-pyridazin-3-one

Edukte

Cc1ccc(-c2cc(CN3CCN(Cc4ccccc4)CC3)c(=O)n(CC(C)C)n2)cc1
( 5 )
Cc1ccc(-c2cc(CN3CCN(Cc4ccccc4)CC3)c(=O)n(CC(C)C)n2)cc1
4-(4-benzyl-1-piperazinyl)methyl-2-isobutyl-6-(4-methylphenyl)-2H-pyridazin-3-one
O=C(O)c1cc(-c2ccc(C(F)(F)F)cc2)n[nH]c1=O
4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (5), 4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow crystalline powder (yield: 88.5%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08