Reaktion #804105

Reaktionsgleichung

tert-butyl 4-(3-(trifluoromethyl)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

→

tert-Butyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperidine-1-carboxylate

Lösungsmittel

methanol

Palladium carbon

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeInto a 50-mL round-bottom flask was purged
2. 2
   Temperaturmaintained with an inert atmosphere of hydrogen
3. 3
   FiltrationThe solids were filtered out
4. 4
   EinengenThe resulting mixture was concentrated under vacuum
5. 5
   SonstigeThis resulted in 379.8 mg (87%) of tert-butyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperidine-1-carboxylate as colorless oil

Vorschrift

Into a 50-mL round-bottom flask was purged and maintained with an inert atmosphere of hydrogen, was added a solution of tert-butyl 4-(3-(trifluoromethyl)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (449.3 mg, 1.27 mmol, 1.00 equiv, 93%) in methanol (20 mL) and Palladium carbon anhydrous (134.8 mg). The resulting solution was stirred overnight at room temperature. The solids were filtered out. The resulting mixture was concentrated under vacuum. This resulted in 379.8 mg (87%) of tert-butyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperidine-1-carboxylate as colorless oil.

Quelle