Reaktion #8035

ord-8a650fee2ff8484493b5687f5a40859d

Reaktionsgleichung

Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
( 7 )
Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
4-carboxy-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccc(C)cc2)nn(CC(C)C)c1=O
2-isobutyl-4-methoxycarbonyl-6-(4-methylphenyl)-2H-pyridazin-3-one
→
Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1
title compound
Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1
4-carboxy-2-isobutyl-6-(4-methylphenyl)-2H-pyridazin-3-one

Edukte

Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
( 7 )
Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
4-carboxy-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccc(C)cc2)nn(CC(C)C)c1=O
2-isobutyl-4-methoxycarbonyl-6-(4-methylphenyl)-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (7), 2-isobutyl-4-methoxycarbonyl-6-(4-methylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow needles (yield: 86.7%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08