Reaktion #8033

ord-40b31dad112f477da22ae7c8e274bb70

Reaktionsgleichung

Cc1ccc(-c2nn(CC(C)C)c(=O)c(N3CCN(C(=O)OC(C)(C)C)CC3)c2C)cc1F
( 10 )
Cc1ccc(-c2nn(CC(C)C)c(=O)c(N3CCN(C(=O)OC(C)(C)C)CC3)c2C)cc1F
4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccccc2)cc(COS(C)(=O)=O)c1=O
2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one
CN1CCNCC1
1-methylpiperazine
→
Cc1c(-c2ccccc2)nn(CC(C)C)c(=O)c1N1CCN(C)CC1
title compound
Ausbeute 77.1%
Cc1c(-c2ccccc2)nn(CC(C)C)c(=O)c1N1CCN(C)CC1
2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-phenyl-2H-pyridazin-3-one
Ausbeute 77.1%

Edukte

Cc1ccc(-c2nn(CC(C)C)c(=O)c(N3CCN(C(=O)OC(C)(C)C)CC3)c2C)cc1F
( 10 )
Cc1ccc(-c2nn(CC(C)C)c(=O)c(N3CCN(C(=O)OC(C)(C)C)CC3)c2C)cc1F
4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccccc2)cc(COS(C)(=O)=O)c1=O
2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one
CN1CCNCC1
1-methylpiperazine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere reacted

Vorschrift

Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 77.1%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08