Reaktion #80317

Reaktionsgleichung

7-(2-bromoethoxy)-6-methoxy-4-(3'-methylanilino)quinazoline

morpholine

→

6-methoxy-4-(3'-methylanilino)-7-(2-morpholinoethoxy)quinazoline

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated
2. 2
   Sonstigethe residue was partitioned between methylene chloride
3. 3
   TrocknenThe organic phase was dried (MgSO4)
4. 4
   Sonstigeevaporated
5. 5
   SonstigeThe residue was triturated under diethyl ether

Vorschrift

A mixture of 7-(2-bromoethoxy)-6-methoxy-4-(3'-methylanilino)quinazoline (0.25 g) and morpholine (4 ml) was stirred at ambient temperature for 4 hours. The mixture was evaporated and the residue was partitioned between methylene chloride and a dilute aqueous sodium bicarbonate solution. The organic phase was dried (MgSO4) and evaporated. The residue was triturated under diethyl ether to give 6-methoxy-4-(3'-methylanilino)-7-(2-morpholinoethoxy)quinazoline (0.198 g), m.p. 168°-170° C.

Quelle