Reaktion #8029

ord-3913574c5e754f0a906e2d6dcd271a96

Reaktionsgleichung

Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
( 7 )
Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
4-carboxy-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccccc2)nn(CC(C)C)c1=O
2-isobutyl-4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one
→
CC(C)Cn1nc(-c2ccccc2)cc(C(=O)O)c1=O
title compound
Ausbeute 82.5%
CC(C)Cn1nc(-c2ccccc2)cc(C(=O)O)c1=O
4-carboxy-2-isobutyl-6-phenyl-2H-pyridazin-3-one
Ausbeute 82.5%

Edukte

Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
( 7 )
Cc1ccc(-c2cc(C(=O)O)c(=O)n(CC(C)C)n2)cc1F
4-carboxy-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccccc2)nn(CC(C)C)c1=O
2-isobutyl-4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (7), 2-isobutyl-4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine-needles (yield: 82.5%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08