Reaktion #8028

ord-0095c865a56e4289b73179372c43aea2

Reaktionsgleichung

COC(=O)c1cc(-c2ccc(C)c(F)c2)nn(CC(C)C)c1=O
( 6 )
COC(=O)c1cc(-c2ccc(C)c(F)c2)nn(CC(C)C)c1=O
6-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccccc2)n[nH]c1=O
4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one
→
COC(=O)c1cc(-c2ccccc2)nn(CC(C)C)c1=O
title compound
Ausbeute 94.1%
COC(=O)c1cc(-c2ccccc2)nn(CC(C)C)c1=O
2-isobutyl-4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one
Ausbeute 94.1%

Edukte

COC(=O)c1cc(-c2ccc(C)c(F)c2)nn(CC(C)C)c1=O
( 6 )
COC(=O)c1cc(-c2ccc(C)c(F)c2)nn(CC(C)C)c1=O
6-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
COC(=O)c1cc(-c2ccccc2)n[nH]c1=O
4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

Following the procedure of Example 1 (6), 4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow oil (yield: 94.1%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087606B2uspto-grants-2006_08