Reaktion #80270

Reaktionsgleichung

N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine

phenyl chloroacetate

→

N-2-((Phenoxycarbonyl)oxy)ethyl-N-((phenoxycarbonyl)methyl)-N,N-dimethyl-ammonium Chloride

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer
2. 2
   workup.ADDITIONinternal thermometer, addition funnel, and argon inlet
3. 3
   workup.ADDITIONAfter addition
4. 4
   Temperaturthe mixture is heated
5. 5
   Temperaturto reflux for 3 h
6. 6
   SonstigeThe cooled mixture is triturated with ether (500 ml)
7. 7
   SonstigeA white solid, 23.15 g (51%) is isolated
8. 8
   Sonstigeto give 9

Vorschrift

To a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer, internal thermometer, addition funnel, and argon inlet are added N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine (25.00 g, 0.120 mol), acetonitrile (100 ml), and phenyl chloroacetate (20.38 g, 0.120 mol) over 5 min. After addition is complete, the mixture is heated to reflux for 3 h. The cooled mixture is triturated with ether (500 ml). A white solid, 23.15 g (51%) is isolated to give 9.

Quelle