Reaktion #80259

Reaktionsgleichung

hydrogen peroxide

isatin

sulfuric acid

→

isatoic acid anhydride

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere charged in a 500 ml two-neck flask
2. 2
   workup.STIRRINGthe mixture was stirred at 60° to 65° C. for one hour
3. 3
   Temperatura half and then cooled
4. 4
   FiltrationThe deposit was filtered
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried under vacuum

Vorschrift

The isatin derivative (70 g) obtained in the above item (i), 200 ml of acetic acid and 0.8 ml of concentrated sulfuric acid were charged in a 500 ml two-neck flask and the mixture was stirred at room temperature. Then, 50 ml of 30% hydrogen peroxide was added dropwise to the mixture. After the completion of dropping, the mixture was stirred at 60° to 65° C. for one hour and a half and then cooled. The deposit was filtered, washed with water and dried under vacuum to give 35 g of a derivative of isatoic acid anhydride represented by the following formula (20): ##STR24##

Quelle