Reaktion #80258

Reaktionsgleichung

chloral

hydroxylammonium chloride

hydrochloride

aniline

isatin

→

isonitrosoacetanilide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeas shown in the following reaction scheme
2. 2
   Sonstigean aqueous solution obtained
3. 3
   Sonstigeis reacted for 0.5 to 2 hours
4. 4
   Temperaturwith heating at 70° to 110° C.

Vorschrift

The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.

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