Reaktion #802181

Reaktionsgleichung

tert-butyl 4-(4-(4-(ethoxycarbonyl)-2-iodooxazol-5-yl)phenyl)piperazine-1-carboxylate

tert-butyl 4-amino-1H-pyrazole-1-carboxylate

cesium carbonate

9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene

→

2-(1H-pyrazol-4-ylamino)-5-(4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)oxazole-4-carboxylic acid

Ausbeute 26.1%

Lösungsmittel

tBuOH

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas degassed
2. 2
   Temperaturunder reflux overnight
3. 3
   Sonstigethe solvent removed in vacuo
4. 4
   SonstigeThe residue was partitioned between water and EtOAc
5. 5
   Extraktionthe aqueous phase extracted with EtOAc and DCM
6. 6
   TrocknenThe combined organic phases were dried over MgSO4
7. 7
   Sonstigethe solvent removed in vacuo
8. 8
   SonstigeThe residue was purified by preparative HPLC

Vorschrift

A mixture of tert-butyl 4-(4-(4-(ethoxycarbonyl)-2-iodooxazol-5-yl)phenyl)piperazine-1-carboxylate (0.150 g, 0.28 mmol), tert-butyl 4-amino-1H-pyrazole-1-carboxylate (0.261 g, 1.42 mmol), cesium carbonate (0.462 g, 2.39 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.012 g, 0.013 mmol) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.0165 g, 0.029 mmol) in tBuOH (4.5 ml) and dioxane (4.5 ml) was degassed, placed under a nitrogen atmosphere and then stirred under reflux overnight. The reaction mixture was passed through a MP-SH cartridge and the solvent removed in vacuo. The residue was partitioned between water and EtOAc and the aqueous phase extracted with EtOAc and DCM. The combined organic phases were dried over MgSO4 and the solvent removed in vacuo. The residue was purified by preparative HPLC to afford 2-(1H-pyrazol-4-ylamino)-5-(4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)oxazole-4-carboxylic acid (0.033 g, 0.073 mmol, 26%). LCMS (2) Rt: 1.68 min; m/z (ES+) 455.

Quelle