Reaktion #80190

Reaktionsgleichung

2-(5-Trifluoromethyl-pyridin-2-yl)-benzoic acid isopropyl ester

lithium hydroxide monohydrate

→

title compound

2-(5-Trifluoromethyl-pyridin-2-yl)-benzoic acid

Lösungsmittel

tetrahydrofuran-methanol water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Sonstigethe volatiles were removed under vacuum and 5 ml of water
3. 3
   workup.ADDITIONwere added to the mixture, which
4. 4
   ExtraktionThe resulting slurry was extracted with ethyl acetate
5. 5
   Trocknenthe combined organic layers were dried (magnesium sulfate)
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated under vacuum

Vorschrift

2-(5-Trifluoromethyl-pyridin-2-yl)-benzoic acid isopropyl ester was dissolved in 10 ml of a 3:1:1 mixture of tetrahydrofuran-methanol-water, and lithium hydroxide monohydrate (161 mg, 3.84 mmol) was added. After stirring for 3 h at room temperature, the volatiles were removed under vacuum and 5 ml of water were added to the mixture, which was brought to pH 6 with 1N HCl. The resulting slurry was extracted with ethyl acetate, the combined organic layers were dried (magnesium sulfate), filtered and concentrated under vacuum to provide the title compound.

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