Reaktion #801122

ord-1b4a9e79fb754935918a82a45204008f

Reaktionsgleichung

Cc1cc(C(F)(F)F)c2cc(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2n1
6-(trans-4-tert-Butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline
Cc1cc(Br)c2cc(O)ccc2n1
4-Bromo-2-methyl-quinolin-6-ol
→
Cc1cc(Br)c2cc(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2n1
4-Bromo-6-(trans-4-tert-butyl-cyclohexyloxy)-2-methyl-quinoline

Edukte

Cc1cc(C(F)(F)F)c2cc(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc2n1
6-(trans-4-tert-Butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline
Cc1cc(Br)c2cc(O)ccc2n1
4-Bromo-2-methyl-quinolin-6-ol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Synthesized as per 6-(trans-4-tert-Butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline using 4-Bromo-2-methyl-quinolin-6-ol as starting material. ESI-MS(M+H+): 378.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09186367B2uspto-grants-2015_11