Reaktion #80080

Reaktionsgleichung

4-bromo-1-bromomethyl-2-methyl-benzene

Intermediate 138

4-bromo-1-bromomethyl-2-methyl-benzene

imidazole

NaH

→

title compound

1-(4-Bromo-2-methyl-benzyl)-1H-imidazole

Lösungsmittel

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution was cooled to room temperature
2. 2
   Einengenconcentrated under reduced pressure

Vorschrift

A solution of imidazole (58.0 mg, 0.86 mmol) in 3 mL DMF was treated with NaH (20.0 mg, 0.86 mmol) and heated to 90° C. After 1 h a solution of 4-bromo-1-bromomethyl-2-methyl-benzene (Intermediate 138, 190.0 mg, 0.72 mmol) in 3 mL DMF was added and stirring at 90° C. continued for 1 hour. The solution was cooled to room temperature and concentrated under reduced pressure. The title compound, 160.0 mg (88%) was isolated by column chromatography (5% MeOH-EtOAc) as a colorless solid.

Quelle