Reaktion #8005

Reaktionsgleichung

3′-fluoro-4′-methylacetophenone

diethyl ketomalonate

→

title compound

Ausbeute 79.3%

ethyl 2-ethoxycarbonyl-4-(3-fluoro-4-methylphenyl)-2-hydroxy-4-oxobutanoate

Ausbeute 79.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto drop back to room temperature
2. 2
   Sonstigethe mixture was purified by column chromatography on silica gel [silica gel 100 g, chloroform/ethyl acetate (10/1)]

Vorschrift

A mixture of 3′-fluoro-4′-methylacetophenone (4.92 g, 32.3 mmol) and diethyl ketomalonate (6.19 g, 35.6 mmol) was stirred at 120° C. for 48 hours. The temperature of the reaction mixture was allowed to drop back to room temperature, and the mixture was purified by column chromatography on silica gel [silica gel 100 g, chloroform/ethyl acetate (10/1)] to yield the title compound as yellow crystals (8.41 9, 79.3%).

Quelle