Reaktion #80047

Reaktionsgleichung

tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

Intermediate 115

tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

HCl

→

1-(4-Bromophenyl)-cyclopropylamine

Lösungsmittel

MeOH

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was quenched
2. 2
   ExtraktionThe mixture was extracted with Et2O
3. 3
   Waschenthe combined organic layers were washed with H2O and saturated aqueous NaCl
4. 4
   Trocknenbefore being dried (MgSO4)
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   SonstigeThe title compound 613 mg (85%) was used without further purification

Vorschrift

To a solution of tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate (Intermediate 115, 1.08 g, 3.40 mmols) in 20 mL MeOH and 20 mL THF was added 20 mL of 3M aqueous HCl. The solution was warmed to 35° C. for 3 hours and then stirred for 17 h at 25° C. The reaction was quenched by adjusting the pH of the solution to 12 with 3M aqueous NaOH. The mixture was extracted with Et2O and the combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound 613 mg (85%) was used without further purification.

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