Reaktion #80036

Reaktionsgleichung

H2O

4-bromo-3-tert-butylphenol

Intermediate 104

4-bromo-3-tert-butylphenol

imidazole

chloro-triisopropylsilane

→

title compound

(4-Bromo-3-tert-butyl-phenoxy)-triisopropyl-silane

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with EtOAc
2. 2
   WaschenThe combined organic layers were washed with H2O and saturated aqueous NaCl
3. 3
   Trocknenbefore being dried (MgSO4)
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 4-bromo-3-tert-butylphenol (Intermediate 104, 1.17 g, 5.10 mmols) and imidazole (520.0 mg, 7.65 mmols) in 10 mL DMF was added chloro-triisopropylsilane (1.18 g, 6.10 mmols). After stirring overnight at room temperature the solution was diluted wirth H2O and extracted with EtOAc. The combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound, 1.80 g (92%), was isolated by column chromatography (0-1.5% EtOAc-hexanes) as a colorless oil.

Quelle