Reaktion #80028

Reaktionsgleichung

4-bromo-3-isopropylphenol

imidazole

chloro-triisopropylsilane

→

title compound

(4-Bromo-3-isopropyl-phenoxy)-triisopropyl-silane

Lösungsmittel

H2O

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with EtOAc
2. 2
   WaschenThe combined organic layers were washed with H2O and saturated aqueous NaCl
3. 3
   Trocknenbefore being dried (MgSO4)
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 4-bromo-3-isopropylphenol (880.0 mg, 4.09 mmols) and imidazole (417.0 mg, 6.13 mmols) in 10 mL DMF was added chloro-triisopropylsilane (946.0 mg, 4.90 mmols). After stirring overnight at room temperature the solution was diluted with H2O and extracted with EtOAc. The combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound, 1.30 g (92%), was isolated by column chromatography (1-2% EtOAc-hexanes) as a colorless oil.

Quelle